diff --git a/src/js/node/http.ts b/src/js/node/http.ts
index 99bc862fde..0024ad4d5f 100644
--- a/src/js/node/http.ts
+++ b/src/js/node/http.ts
@@ -16,9 +16,9 @@ const enum NodeHTTPIncomingRequestType {
   NodeHTTPResponse,
 }
 const enum NodeHTTPHeaderState {
-  none,
-  assigned,
-  sent,
+  none = 0,
+  assigned = 1 << 0,
+  sent = 1 << 1,
 }
 const enum NodeHTTPBodyReadState {
   none,
@@ -198,7 +198,7 @@ function validateMsecs(numberlike: any, field: string) {
   if (numberlike > TIMEOUT_MAX) {
     process.emitWarning(
       `${numberlike} does not fit into a 32-bit signed integer.` + `\nTimer duration was truncated to ${TIMEOUT_MAX}.`,
-      "TimeoutOverflowWarning"
+      "TimeoutOverflowWarning",
     );
     return TIMEOUT_MAX;
   }
@@ -1668,7 +1668,7 @@ const OutgoingMessagePrototype = {
   },
 
   removeHeader(name) {
-    if (this[headerStateSymbol] === NodeHTTPHeaderState.sent) {
+    if (this[headerStateSymbol] >= NodeHTTPHeaderState.assigned) {
       throw $ERR_HTTP_HEADERS_SENT("Cannot remove header after headers have been sent.");
     }
     const headers = this[headersSymbol];
@@ -1683,6 +1683,41 @@ const OutgoingMessagePrototype = {
     return this;
   },
 
+  setHeaders(headers) {
+    if (this[headerStateSymbol] >= NodeHTTPHeaderState.assigned) {
+      throw $ERR_HTTP_HEADERS_SENT("set");
+    }
+
+    if (!headers || Array.isArray(headers) || typeof headers.keys !== "function" || typeof headers.get !== "function") {
+      throw $ERR_INVALID_ARG_TYPE("headers", ["Headers", "Map"], headers);
+    }
+
+    // Headers object joins multiple cookies with a comma when using
+    // the getter to retrieve the value,
+    // unless iterating over the headers directly.
+    // We also cannot safely split by comma.
+    // To avoid setHeader overwriting the previous value we push
+    // set-cookie values in array and set them all at once.
+    const cookies = [];
+
+    for (const [key, value] of headers) {
+      if (key === "set-cookie") {
+        if (Array.isArray(value)) {
+          cookies.push(...value);
+        } else {
+          cookies.push(value);
+        }
+        continue;
+      }
+      this.setHeader(key, value);
+    }
+    if (cookies.length) {
+      this.setHeader("set-cookie", cookies);
+    }
+
+    return this;
+  },
+
   hasHeader(name) {
     const headers = this[headersSymbol];
     if (!headers) return false;
@@ -1930,9 +1965,7 @@ const ServerResponsePrototype = {
   _removedContLen: false,
   _hasBody: true,
   get headersSent() {
-    return (
-      this[headerStateSymbol] === NodeHTTPHeaderState.sent || this[headerStateSymbol] === NodeHTTPHeaderState.assigned
-    );
+    return this[headerStateSymbol] >= NodeHTTPHeaderState.assigned;
   },
   set headersSent(value) {
     this[headerStateSymbol] = value ? NodeHTTPHeaderState.sent : NodeHTTPHeaderState.none;
@@ -2208,6 +2241,41 @@ const ServerResponsePrototype = {
     return this;
   },
 
+  setHeaders(headers) {
+    if (this[headerStateSymbol] >= NodeHTTPHeaderState.assigned) {
+      throw $ERR_HTTP_HEADERS_SENT("set");
+    }
+
+    if (!headers || Array.isArray(headers) || typeof headers.keys !== "function" || typeof headers.get !== "function") {
+      throw $ERR_INVALID_ARG_TYPE("headers", ["Headers", "Map"], headers);
+    }
+
+    // Headers object joins multiple cookies with a comma when using
+    // the getter to retrieve the value,
+    // unless iterating over the headers directly.
+    // We also cannot safely split by comma.
+    // To avoid setHeader overwriting the previous value we push
+    // set-cookie values in array and set them all at once.
+    const cookies = [];
+
+    for (const [key, value] of headers) {
+      if (key === "set-cookie") {
+        if (Array.isArray(value)) {
+          cookies.push(...value);
+        } else {
+          cookies.push(value);
+        }
+        continue;
+      }
+      this.setHeader(key, value);
+    }
+    if (cookies.length) {
+      this.setHeader("set-cookie", cookies);
+    }
+
+    return this;
+  },
+
   assignSocket(socket) {
     if (socket._httpMessage) {
       throw ERR_HTTP_SOCKET_ASSIGNED();
diff --git a/test/js/node/test/parallel/test-http-response-setheaders.js b/test/js/node/test/parallel/test-http-response-setheaders.js
new file mode 100644
index 0000000000..2f52c54a49
--- /dev/null
+++ b/test/js/node/test/parallel/test-http-response-setheaders.js
@@ -0,0 +1,174 @@
+'use strict';
+const common = require('../common');
+const http = require('http');
+const assert = require('assert');
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    res.writeHead(200); // Headers already sent
+    const headers = new globalThis.Headers({ foo: '1' });
+    assert.throws(() => {
+      res.setHeaders(headers);
+    }, {
+      code: 'ERR_HTTP_HEADERS_SENT'
+    });
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert.strictEqual(res.headers.foo, undefined);
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    assert.throws(() => {
+      res.setHeaders(['foo', '1']);
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    assert.throws(() => {
+      res.setHeaders({ foo: '1' });
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    assert.throws(() => {
+      res.setHeaders(null);
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    assert.throws(() => {
+      res.setHeaders(undefined);
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    assert.throws(() => {
+      res.setHeaders('test');
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    assert.throws(() => {
+      res.setHeaders(1);
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE'
+    });
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert.strictEqual(res.headers.foo, undefined);
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new globalThis.Headers({ foo: '1', bar: '2' });
+    res.setHeaders(headers);
+    res.writeHead(200);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert.strictEqual(res.statusCode, 200);
+      assert.strictEqual(res.headers.foo, '1');
+      assert.strictEqual(res.headers.bar, '2');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new globalThis.Headers({ foo: '1', bar: '2' });
+    res.setHeaders(headers);
+    res.writeHead(200, ['foo', '3']);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert.strictEqual(res.statusCode, 200);
+      assert.strictEqual(res.headers.foo, '3'); // Override by writeHead
+      assert.strictEqual(res.headers.bar, '2');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new Map([['foo', '1'], ['bar', '2']]);
+    res.setHeaders(headers);
+    res.writeHead(200);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert.strictEqual(res.statusCode, 200);
+      assert.strictEqual(res.headers.foo, '1');
+      assert.strictEqual(res.headers.bar, '2');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new Headers();
+    headers.append('Set-Cookie', 'a=b');
+    headers.append('Set-Cookie', 'c=d');
+    res.setHeaders(headers);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert(Array.isArray(res.headers['set-cookie']));
+      assert.strictEqual(res.headers['set-cookie'].length, 2);
+      assert.strictEqual(res.headers['set-cookie'][0], 'a=b');
+      assert.strictEqual(res.headers['set-cookie'][1], 'c=d');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}
+
+{
+  const server = http.createServer({ requireHostHeader: false }, common.mustCall((req, res) => {
+    const headers = new Map();
+    headers.set('Set-Cookie', ['a=b', 'c=d']);
+    res.setHeaders(headers);
+    res.end();
+  }));
+
+  server.listen(0, common.mustCall(() => {
+    http.get({ port: server.address().port }, (res) => {
+      assert(Array.isArray(res.headers['set-cookie']));
+      assert.strictEqual(res.headers['set-cookie'].length, 2);
+      assert.strictEqual(res.headers['set-cookie'][0], 'a=b');
+      assert.strictEqual(res.headers['set-cookie'][1], 'c=d');
+      res.resume().on('end', common.mustCall(() => {
+        server.close();
+      }));
+    });
+  }));
+}